PDE5 Inhibitors vs. GAINSWave®: The Ultimate Treatment Comparison Guide

Erectile dysfunction (ED) is a common condition that research shows affects up to 50 million men. (1) However, advancements in treatment options have given men more choices than ever before. Two of the most popular approaches—PDE5 inhibitors and GAINSWave® therapy—offer distinct benefits. But which one is right for you?

In this guide, we break down the differences between PDE5 inhibitors and GAINSWave® therapy, as well as the pros and cons of each option, so you can make an informed decision for your health.

PDE5 Inhibitors: How They Work and Their Benefits

PDE5 inhibitors are a class of oral medications that improve erectile function by increasing blood flow to the penis. (2) These medications, including sildenafil (Viagra) and tadalafil (Cialis), work by blocking the enzyme phosphodiesterase type 5 (PDE5), which regulates blood vessel constriction.

Mechanism of Action and Key Benefits

By enhancing nitric oxide levels, PDE5 inhibitors relax the blood vessels, leading to improved circulation and stronger erections. Their key benefits include:

• Enhanced blood flow for improved erectile function
• Quick onset of action, with effects lasting from a few hours to over a day
• Well-researched and widely prescribed for ED treatment

Considerations and Potential Side Effects

While effective, PDE5 inhibitors can cause side effects such as headaches, flushing, nasal congestion, and, in rare cases, vision disturbances. (3) They are also not recommended for men taking nitrates or those with certain cardiovascular conditions.

GAINSWave® Therapy: A Non-Invasive Approach to ED

For those looking for a non-pharmaceutical alternative to PDE5 inhibitors, GAINSWave® therapy offers an innovative approach to ED treatment. Using low-intensity shockwaves (LI-ESWT) this therapy stimulates tissue repair and enhances natural erectile function.

How GAINSWave® Works and Its Benefits

GAINSWave® therapy promotes angiogenesis (the formation of new blood vessels) and breaks down microplaque in existing blood vessels, improving natural erectile function. (4) Benefits of GAINSWave® therapy include:

• Stimulates angiogenesis for better circulation
• Drug-free, non-invasive approach to ED treatment
• Long-term improvements in erectile function

Considerations and Potential Side Effects

GAINSWave® therapy requires multiple treatment sessions, with benefits becoming noticeable over time. Some patients report mild discomfort during treatment, but side effects are generally minimal compared to oral medications.

Comparing PDE5 Inhibitors and GAINSWave® Therapy

Choosing between PDE5 inhibitors and GAINSWave® therapy requires a close look at their effectiveness, mechanisms, and treatment outcomes. Both methods can be effective, but the specific option that works best for you can depend on several factors, including your age, how quickly you need results, and the severity of your ED.

Mechanisms and Treatment Outcomes

PDE5 inhibitors work by temporarily increasing blood flow, offering immediate erectile function improvements. In contrast, GAINSWave® therapy aims to restore natural function over time, addressing the root causes of ED rather than just the symptoms.

Quantitative Efficacy Metrics

PED5 inhibitors work quickly, but only last for a few hours at a time. Research has shown them to be highly effective at treating ED, with a success rate of between 60-80%. (5) However, between 10-20% can experience symptoms, which may include headaches and flushing.

GAINSWave® therapy provides gradual improvement rather than the quick fix of PED5 inhibitors. However, they can provide more long-lasting benefits that often last months, or even years. Research has shown GAINSWave® therapy to be mostly effective with about 60% of patients noticing improvement. (6) However, few if any patients experience difficulties with side effects.

Hormonal and Vascular Impacts

Both GAINSWave® therapy and PED5 inhibitors produce increased blood flow and erectile quality. The combined effect of both may deliver the best possible results, although you should consult with your doctor before combining treatments.

Patient Suitability for PDE5 Inhibitors and GAINSWave® Therapy

Before deciding on which treatment option is best for you, it’s important to know if you’re better suited for PDE4 inhibitors or GAINSWave® therapy. 

Men seeking immediate results, particularly those without contradictions for ED medications, are likely better off going with PDE5 inhibitors, although it’s important to first consult with your doctor.

Research has shown that men taking nitrates, those with severe liver impairment, those with a history of heart failure, and those with hemostatic or bleeding disorders should not take PDE5 inhibitors. (2)

GAINSWave® Therapy is a great option for men seeking a long-term, medication-free solution that targets the underlying vascular causes of ED. Although GAINSWave® therapy is a safe option for most men, those with active prostate cancer or penile implants should avoid shockwave therapy. (7)

Enhancing Treatment Success: Lifestyle and Complementary Strategies

In addition to medical treatments, lifestyle choices play a crucial role in ED management. Incorporating healthy lifestyle choices can significantly enhance the effectiveness of ED treatments.

Lifestyle Modifications to Boost ED Treatment Results

• Maintaining a heart-healthy diet
• Engaging in regular exercise
• Managing stress
• Getting quality sleep
• Limiting the use of tobacco and alcohol

Conclusion: Choosing the Right ED Treatment Path

Advancements in ED treatments continue to evolve, offering men more choices than ever. Whether opting for PDE5 inhibitors, GAINSWave® therapy, or a combination of the two, understanding your long-term goals for treating ED, as well as the benefits and drawbacks of each option will help you make the best decision for your health.

When you’re ready to take the next steps toward curing your ED, talk to your doctor about which treatment option is best for you.

References

1. Definition & Facts for Erectile Dysfunction
2. PDE5 Inhibitors
3. Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review
4. The Science Behind Gainswave: How It Works and Why It’s Effective
5. PDE5 inhibitors: considerations for preference and long-term adherence
6. Twelve-Month Efficacy and Safety of Low-Intensity Shockwave Therapy for Erectile Dysfunction in Patients Who Do Not Respond to Phosphodiesterase Type 5 Inhibitors
7. Erectile Dysfunction: Stop Playing The Pill Game